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| UNIBIOCHEM owns a high-standard R&D center with hundreds of dedicated R&D engineers with educational background of Ph. D or Master degree working there. We have facilities of several Kilo-labs with volumes from 10L to 100L and a cGMP compliant multi-purpose pilot plant which can processing pilot scale up for many projects at the same time. We also own various world advanced analytical equipments, high speed and convenient Internet database. | ||||||||||||||||||||||||
| Protected amino acids | ||||||||||||||||||||||||
| Both solid phase and solution phase peptide syntheses are demanding a growing array of protected amino acids. These peptide syntheses require amine protection, side-chain protection, and often acid activation or protection. The addition order of the protecting groups can have a significant influence on both the cost and quality of a particular derivative. UNIBIOCHEM has extensive experience in kilos-to-tons manufacturing of this wide array of protected amino acids. UNIBIOCHEM has emerged as a reliable, high-quality source for over 400 amino acid derivatives for the synthesis of therapeutic peptides and peptidomimetics. | ||||||||||||||||||||||||
| Synthesis of protected amino acids include: | ||||||||||||||||||||||||
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| Unnatural amino acids | ||||||||||||||||||||||||
| Unnatural amino acids, their derivatives, and small peptides continue to gain importance in drug development. Reliable, cost-effective commercial supply of these intermediates is crucial for a successful drug launch. UNIBIOCHEM employs the most cost-effective manufacturing processes to provide high-quality, reproducible Unnatural amino acids on an industrial scale. We have developed expertise in both enzymatic and chemical routes to unnatural amino acids. UNIBIOCHEM's catalog presents more than 120 parent unnatural amino acids, all available on a research scale as D- and L-enantiomers with chiral purity exceeding 99%. | ||||||||||||||||||||||||
| The acylase route is a well-established, cost-effective process for producing both enantiomers of many unnatural amino acids. Hydantoinase enzymes can be used to provide high yields of high-purity D form amino acids. Other enzymes, including transaminase and nitrilase, are also evaluated in select situations. | ||||||||||||||||||||||||
| Solution phase synthesis | ||||||||||||||||||||||||
| UNIBIOCHEM has also developed expertise in the solution phase manufacture of small peptides, the ultimate products most often derived from amino acids. The choices of protection group, activating group, order of addition and coupling agent lead to numerous alternate potential peptide synthesis routes. Our experience in the manufacture of the protected amino acids as well as solution phase coupling allows us to quickly target the most cost effective process. UNIBIOCHEM's efficient production of amino acid derivatives provides the critical raw materials for peptide fragments, which we have manufactured by solution phase on a metric ton scale. | ||||||||||||||||||||||||
| Amino alcohols | ||||||||||||||||||||||||
| Amino alcohols are important amino acid derivatives used in chiral auxiliaries and as chiral building blocks. | ||||||||||||||||||||||||
| Custom chiral intermediates | ||||||||||||||||||||||||
| UNIBIOCHEM takes its specialty amino acids downstream to the manufacture of many complex chiral intermediates. Multiple adjacent chiral centers, required for an increasing number of developmental drugs, can be accessed through amino acid derivative chemistry. The chemistry required for these derivatives, including hydrogenation, Grignard and hydride additions, condensations reactions and others, has been practiced on a multi-ton scale at UNIBIOCHEM. Most of this chemistry is carried out under confidentiality protocol. UNIBIOCHEM welcomes your confidential inquiries for multi-step custom manufacturing of similar products and other organic intermediates required in drug discovery and development programs. | ||||||||||||||||||||||||
| Synthesis of fine chemicals include: | ||||||||||||||||||||||||
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